Lithocarpus litseifolius leaf extract and its flavonoids alleviate hyperuricemia via TLR2/PI3K/NF-κ B pathway inhibition and gut microbiota modulation

蔡少逸; Yuanyuan Chen; Tao Luo; Guangqiang Ma; Yu Zhong; Ailan Wu; Shuhong Peng; Chengdong Liao; Hua Zhang; Changhua Zhang; Lan Cao

doi:10.1039/d5fo05398f

January 1, 2026Food & Function

Lithocarpus litseifolius leaf extract and its flavonoids alleviate hyperuricemia via TLR2/PI3K/NF-κ B pathway inhibition and gut microbiota modulation

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Key Points

This research aims to explore the effects of Lithocarpus litseifolius leaf extract and its flavonoids on hyperuricemia.
Examined the therapeutic effects of Lithocarpus litseifolius leaf extract and five key flavonoids.
Investigated TLR2/PI3K/NF-κB pathway inhibition and gut microbiota modulation.
Lithocarpus litseifolius leaf extract significantly reduced uric acid levels, indicating therapeutic potential for hyperuricemia.
Inhibition of TLR2/PI3K/NF-κB signaling pathways was observed, contributing to its effect.

Implication

Demonstrates the effects of Lithocarpus litseifolius leaf extract on hyperuricemia, suggesting potential therapeutic uses.

Abstract

Lithocarpus litseifolius (Hance) Chun (Lithocarpus polystachyus rehd.) is a medicinal and edible plant. This study investigated the therapeutic effects of Lithocarpus litseifolius (LLL) leaf extract and its five key flavonoids...

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Cite This Study

蔡少逸 et al. (2026) studied this question.

synapsesocial.com/papers/69edac9b4a46254e215b45f8 https://doi.org/10.1039/d5fo05398f

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Lithocarpus litseifolius leaf extract and its flavonoids alleviate hyperuricemia via TLR2/PI3K/NF-κ B pathway inhibition and gut microbiota modulation

Key Points

Implication

Abstract

Discussion

Cite This Study

Lithocarpus litseifolius leaf extract and its flavonoids alleviate hyperuricemia via TLR2/PI3K/NF-κ B pathway inhibition and gut microbiota modulation

Key Points

Implication

Abstract

Discussion

Cite This Study

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