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April 26, 2026World Journal of Surgical OncologyOpen Access

LncRNA LINC01579/miR-579-3p axis promotes gastric cancer progression via NOTCH1 pathway

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Authors

YGYuqing GengSGShixia GongQXQing Xue

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Overview

Randomized trial reveals the role of LINC01579 in gastric cancer progression, suggesting its potential as a therapeutic target.

Key Points

  • This study investigates the role of LINC01579 in the progression of gastric cancer and its prognostic significance.
  • Included 100 gastric cancer subjects to measure LINC01579, miR-579-3p, and NOTCH1 signaling-related genes.
  • Used qRT-PCR, Kaplan-Meier estimator, and Cox analysis for evaluation.
  • Conducted dual-luciferase reporter assays and CCK-8 assay to assess function.
  • LINC01579 was elevated in GC tissues, linked to advanced pTNM stage and poor overall survival (p<0.05).
  • LINC01579 directly targeted miR-579-3p, showing a significant negative correlation.
  • LINC01579 enhanced cell proliferation and NOTCH1 signaling while inhibiting apoptosis (p<0.01).

Cite This Study

Geng et al. (2026) studied this question.

synapsesocial.com/papers/69edacbd4a46254e215b4721https://doi.org/10.1186/s12957-026-04339-x
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