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April 26, 2026OncogeneOpen Access

Targeting VPS4 elicits STING-driven anti-tumor immunity to suppress rhabdomyosarcoma growth

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Authors

RZRay ZhangLCLonggui ChenXLXinwen Liang

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Overview

Randomized trial demonstrates tumor growth suppression in rhabdomyosarcoma, suggesting a new therapeutic strategy.

Key Points

  • This research investigates how inhibiting VPS4 affects tumor growth and boosts anti-tumor immunity in rhabdomyosarcoma.
  • Used pharmacological and genetic approaches to inhibit VPS4 in murine rhabdomyosarcoma models.
  • Analyzed immune signaling pathways activated by VPS4 inhibition, focusing on the cGAS-STING-TBK1-IRF3 axis.
  • Monitored tumor growth rates and immune cell infiltration following VPS4 inhibition.
  • VPS4 inhibition led to significant tumor growth suppression in RMS (p<0.05).
  • Cytokine signaling was markedly increased, with an activation of the cGAS-STING pathway (p<0.01).
  • Loss of STING reduced immune cell infiltration by natural killer and dendritic cells, impairing anti-tumor effects (p<0.05).

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69edacbd4a46254e215b4723https://doi.org/10.1038/s41388-026-03800-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Combining <scp>VPS34</scp> inhibitors with <scp>STING</scp> agonists enhances type I interferon signaling and anti‐tumor efficacy2024 · 7 citations
  2. 2Unleashing anti-tumor immunity: Targeting the autophagy-related protein VPS34 to enhance STING agonist-based therapy2024
  3. 3VPS34 in Autophagy, Cancer, and Cancer Therapy2026
  4. 4VPS34-IN1 inhibits cap-mediated translation and synergizes with STING to drive type-I IFN expression in human plasmacytoid DCs2024 · 1 citations
  5. 5Targeting VCP enhances colorectal cancer therapy through STING stabilization2025