⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

January 1, 2026RSC Medicinal Chemistry

Design, synthesis and pharmacological evaluation of 3 H -spiro[benzofuran-2,4′-piperidine] IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma

Zhiwei Chen Qi Zhang Yun Chen Yi Ning Q-i Zhang Mengxiao Zhang Qiupei Liu Yi Xue Linjiang Tong Jian Ding Hua Xie Wenhu Duan

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to identify effective IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma (DLBCL).
Designed and synthesized a series of 3 H -spiro[benzofuran-2,4′-piperidine] compounds.
Conducted pharmacological evaluations to assess their efficacy as DLBCL treatments.
Identified multiple novel IRAK4 inhibitors with significant anti-DLBCL activity.
Demonstrated promising pharmacological properties supporting clinical exploration.

Implication

Explores IRAK4 inhibitors in diffuse large B-cell lymphoma, suggesting new treatment options.

Abstract

We report the discovery of a new series of 3 H -spiro[benzofuran-2,4′-piperidine] IRAK4 inhibitors as potential anti-DLBCL agents.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69edad6b4a46254e215b514d https://doi.org/10.1039/d6md00025h

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Discovery of IRAK4 Inhibitors <b>BAY1834845</b> (Zabedosertib) and <b>BAY1830839</b>Original Research · 2024 · 37 citations
2Design and synthesis of novel <i>N</i> -phenyl-4-pyrimidine-diamine BCL6 inhibitors with <i>anti</i> -tumor activities2025 · 2 citations
3A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors2024 · 10 citations
4Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation2024 · 9 citations
5The Discovery of 7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-<i>N</i>-(6-methylpyrazolo[1,5-<i>a</i>]pyrimidin-3-yl)imidazo[1,2-<i>a</i>]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke2024 · 24 citations

Discovery and in Vivo Evaluation of Dual PI3Kβ/δ Inhibitors2012
A Comprehensive Review on IRAK-4 Inhibitors2025
Discovery of Indazole-Based Selective IRAK4 Inhibitors2024
Research process of iminosugars in glycosidase inhibition and hypoglycemic activityRSC Medicinal Chemistry · 2026
Rational design of an environment-sensitive fluorescent probe for monitoring butyrylcholinesterase activity and its application in Alzheimer's diseaseRSC Medicinal Chemistry · 2026

More from RSC Medicinal Chemistry

More from Chinese Academy of Sciences

More from University of Chinese Academy of Sciences

More from Shanghai Institute of Materia Medica

More from University of Nottingham Ningbo China