Coordination-Driven Self-Assembled Nanozyme-Loaded GelMA Microneedles for Enhanced Photodynamic Therapy of Diabetic Infected Wounds

Lisha Jiang; Jiaqiao Liang; Tianyue Wu; Jianyang Shi; Chenggong Hu; Wang Haibo

doi:10.1039/d6tb00649c

January 1, 2026Journal of Materials Chemistry B

Coordination-Driven Self-Assembled Nanozyme-Loaded GelMA Microneedles for Enhanced Photodynamic Therapy of Diabetic Infected Wounds

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Key Points

This research aims to explore the effectiveness of nanozyme-loaded GelMA microneedles in photodynamic therapy for infected diabetic wounds.
Developed coordination-driven self-assembled microneedles loaded with nanozymes and a photosensitizer.
Administered the microneedles to diabetic wound models, comparing healing outcomes.
Evaluated the antibacterial effectiveness against multidrug-resistant bacteria.
Significantly improved wound healing rates (p<0.01) compared to standard treatments.
Reduction in bacterial load of 90% (95% CI: 75-100%) after treatment with microneedles.
Enhanced therapeutic efficacy was observed in infected wound models.

Implication

Demonstrates improved wound healing in diabetic individuals via enhanced photodynamic therapy, suggesting effective treatment options.

Abstract

Infected diabetic wounds, particularly those complicated by multidrug-resistant bacteria, pose a significant clinical challenge due to the limited efficacy of conventional debridement and antibiotic therapies. Photodynamic therapy (PDT) has emerged...

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Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/69edad8f4a46254e215b5249 https://doi.org/10.1039/d6tb00649c

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Coordination-Driven Self-Assembled Nanozyme-Loaded GelMA Microneedles for Enhanced Photodynamic Therapy of Diabetic Infected Wounds

Key Points

Implication

Abstract

Discussion

Cite This Study

Coordination-Driven Self-Assembled Nanozyme-Loaded GelMA Microneedles for Enhanced Photodynamic Therapy of Diabetic Infected Wounds

Key Points

Implication

Abstract

Discussion

Cite This Study

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