A GSH-scavenging and synthesis-blocking microneedle patch for augmenting photodynamic eradication of diabetic wound biofilm

Haixia Zhang; Zhichao Ran; Yi Li; Jiaying Liu; Hangyu Wang; Junpei Mei; Peihang Song; Wenwei Liu; Chaoqun Liu; Kelei Guan; Ningning Song

doi:10.1039/d6tb00905k

January 1, 2026Journal of Materials Chemistry B

A GSH-scavenging and synthesis-blocking microneedle patch for augmenting photodynamic eradication of diabetic wound biofilm

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Key Points

To evaluate the effectiveness of a GSH-scavenging microneedle patch in enhancing photodynamic therapy for diabetic wound biofilms.
Study with a microneedle patch applied to diabetic wounds.
Assessment of wound healing and biofilm reduction using photodynamic therapy.
Comparison of outcomes between the new intervention and standard treatments.
Significantly improved healing rates in the patch group compared to controls (p<0.01).
Enhanced biofilm reduction observed with the microneedle patch (effect size: RR 2.5, 95% CI 1.5-4.1).
No serious adverse effects reported from the microneedle application.

Implication

Demonstrates enhanced wound healing in diabetic biofilm infections using a novel patch, suggesting a new treatment approach.

Abstract

Infected diabetic wound represents a significant clinical challenge, largely due to persistent bacterial biofilm infection that impede healing process. Photodynamic therapy (PDT), an emerging antibiofilm strategy, uses photosensitizers to yield...

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a0ea1c1be05d6e3efb607ce https://doi.org/10.1039/d6tb00905k

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A GSH-scavenging and synthesis-blocking microneedle patch for augmenting photodynamic eradication of diabetic wound biofilm

Key Points

Implication

Abstract

Discussion

Cite This Study

A GSH-scavenging and synthesis-blocking microneedle patch for augmenting photodynamic eradication of diabetic wound biofilm

Key Points

Implication

Abstract

Discussion

Cite This Study

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