Controlled delivery of IL-10 and retinoic acid for the treatment of psoriasis using a multilayered microneedle

Nathaniel Wright; Priya Bhashyam; Lea Seo; Tim Wu; Alexander I. McGurk; Marinel Ocasio‐Rivera; Anthony R. D’Amato; Deborah J. Fowell; Yadong Wang

doi:10.1039/d5pm00233h

January 1, 2026RSC PharmaceuticsOpen Access

Controlled delivery of IL-10 and retinoic acid for the treatment of psoriasis using a multilayered microneedle

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Key Points

To investigate a new system for effectively delivering IL-10 and retinoic acid for psoriasis treatment.
Developed a microneedle system for controlled release of therapeutic agents.
Focused on localized targeting and time-dependent release mechanisms.
Examined the combined efficacy of IL-10 and retinoic acid in coacervate form.
Demonstrated successful localized delivery of IL-10 and retinoic acid.
Showed improved therapeutic outcomes in psoriasis models compared to conventional treatments.

Implication

Explores localized treatment with immunotherapy for psoriasis, suggesting new therapeutic potentials.

Abstract

Here we report a novel immunotherapeutic system capable of localized targeting with time dependent release of small and biological molecules. This is the first coacervate microneedle combination product.

Discussion

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Cite This Study

Wright et al. (2026) studied this question.

synapsesocial.com/papers/69edae394a46254e215b588b https://doi.org/10.1039/d5pm00233h

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Controlled delivery of IL-10 and retinoic acid for the treatment of psoriasis using a multilayered microneedle

Key Points

Implication

Abstract

Discussion

Cite This Study

Controlled delivery of IL-10 and retinoic acid for the treatment of psoriasis using a multilayered microneedle

Key Points

Implication

Abstract

Discussion

Cite This Study

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