October 1, 2014European Heart Journal437 citations

Paravalvular regurgitation after transcatheter aortic valve replacement with the Edwards sapien valve in the PARTNER trial: characterizing patients and impact on outcomes

SKS. Kodali PPPhilippe Pîbarot PDPamela S. Douglas

Structured PICO

Does the severity of paravalvular regurgitation after TAVR impact 1-year mortality?

Population

Patients undergoing transcatheter aortic valve replacement with the Edwards SAPIEN valve in the PARTNER trial

Intervention

Transcatheter aortic valve replacement with the Edwards SAPIEN valve

Comparator

Different severities of paravalvular regurgitation (none/trace vs mild vs moderate/severe)

Outcome

1-year mortalityhard clinical

Both mild and moderate/severe paravalvular regurgitation after TAVR are associated with increased 1-year mortality.

Abstract

Differences in baseline characteristics in patients with increasing severities of PVR may increase the risk of this complication. Despite these differences, multivariable analysis demonstrated that both mild and moderate/severe PVR predicted higher 1-year mortality.

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