Paravalvular regurgitation after transcatheter aortic valve replacement with the Edwards sapien valve in the PARTNER trial: characterizing patients and impact on outcomes

Why the study?

Does the severity of paravalvular regurgitation after TAVR impact 1-year mortality?

Structured PICO

Does the severity of paravalvular regurgitation after TAVR impact 1-year mortality?

P

Population

Patients undergoing transcatheter aortic valve replacement with the Edwards SAPIEN valve in the PARTNER trial

I

Intervention

Transcatheter aortic valve replacement with the Edwards SAPIEN valve

C

Comparator

Different severities of paravalvular regurgitation (none/trace vs mild vs moderate/severe)

O

Outcome

1-year mortalityhard clinical

Both mild and moderate/severe paravalvular regurgitation after TAVR are associated with increased 1-year mortality.

Answers are grounded in this paper and cite their sources.

Post-TAVR PVR assessment refines mortality risk stratification; leaves open whether mitigating mild regurgitation improves survival.

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Kodali et al. (2014) studied this question.

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