Postnatal left ventricular mass z-score was weakly but independently associated with hospital length of stay (R2=0.055; p=0.002) and maximum glucose infusion rate in infants of diabetic mothers.
Cohort (n=112)
Is postnatal left ventricular mass z-score associated with hospital length of stay and glucose infusion needs in infants of diabetic mothers?
Postnatal left ventricular mass measured by echocardiography in the first week of life is independently associated with total hospital length of stay and maximum glucose infusion rate in infants of diabetic mothers.
Effect estimate: R2 0.055
p-value: p=0.002
Abstract We aimed to assess the relationship between postnatal left ventricular mass (LVM) z-score and clinical outcomes among infants of diabetic mothers (IDMs). We performed a retrospective cohort study of infants born to mothers with pregestational diabetes mellitus. The primary predictor was postnatal LVM z-score; the primary outcome was hospital length of stay (LOS). A secondary outcome was maximum glucose infusion rate (GIR) during hospitalization. There were 112 infants who met the inclusion criteria (52% male). After multiple linear regression, there was a weak relationship between LVM z-score and LOS (R2 = 0.055; p = 0.002); the relationship between LVM z-score and maximum GIR was somewhat stronger (R2 = 0.205, p < 0.001). LVM measured by echocardiography during the first week of life is weakly but independently associated with total LOS and maximum GIR among infants born to mothers with pregestational diabetes mellitus. The impact of left ventricular hypertrophy in IDMs on clinical outcomes should be considered in clinical context.
Kannan et al. (Sat,) conducted a cohort in Infants of diabetic mothers (n=112). Postnatal left ventricular mass (LVM) z-score was evaluated on Hospital length of stay (LOS) (R2 0.055, p=0.002). Postnatal left ventricular mass z-score was weakly but independently associated with hospital length of stay (R2=0.055; p=0.002) and maximum glucose infusion rate in infants of diabetic mothers.