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November 9, 1999CirculationOpen Access

Serum From Patients With Severe Heart Failure Downregulates eNOS and Is Proapoptotic

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Population

In vitro model exposed to serum from patients with severe congestive heart failure (CHF)

Design

Preclinical

Authors

LALaura AgnolettiUniversity of FerraraSCSalvatore CurelloInterventional CardiologyTBTiziana BachettiHeart Failure / Cardiomyopathy

Discussion

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Overview

May contribute to endothelial dysfunction via TNF-alpha in severe CHF; leaves open clinical translation from this animal model.

Structured PICO

P
Population
In vitro model exposed to serum from patients with severe congestive heart failure (CHF)
I
Intervention
Serum from patients with severe CHF
O
Outcome
eNOS expression and apoptosissurrogate

Severe heart failure serum contains circulating factors, including TNF-alpha, that directly promote endothelial dysfunction and apoptosis.

Cite This Study

Agnoletti et al. (1999) studied this question.

synapsesocial.com/papers/69eedeea0fb71af24d31160ahttps://doi.org/10.1161/01.cir.100.19.1983

Topics

Heart failureHFrEF treatment
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Also Consider

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  1. 1The biochemistry of programmed cell death1995 · 997 citations
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  3. 3Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure1990 · 2,603 citations