C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease: the BiomarCaRE project

Natalie Arnold; Christopher Blaum; Alina Goßling; Fabian J. Brunner; Benjamin Bay; Maurizio Ferrario; Paolo Brambilla; Giancarlo Cesana; Valerio Leoni; Luigi Palmieri; Chiara Donfrancesco; Teresa Padró; Jonas Andersson; Pekka Jousilahti; Francisco Ojeda; Tanja Zeller; Allan Linneberg; Stefan Söderberg; Licia Iacoviello; Francesco Gianfagna; Susana Sans; Giovanni Veronesi; Barbara Thorand; Annette Peters; Hugh Tunstall‐Pedoe; Frank Kee; Veikko Salomaa; Renate B. Schnabel; Kari Kuulasmaa; Stefan Blankenberg; Wolfgang Köenig; Christoph Waldeyer

doi:10.1093/eurheartj/ehad867

Key Points

To evaluate whether C-reactive protein levels modify the association between lipoprotein(a) and primary versus recurrent coronary heart disease events.
Analyzed participants from the BiomarCaRE project, stratified by the presence or absence of coronary heart disease (CHD) at baseline.
Assessed incident and recurrent CHD risk associated with lipoprotein(a) [Lp(a)] across categories of high-sensitivity C-reactive protein (hsCRP).
In individuals free of coronary heart disease at baseline, Lp(a) was significantly associated with incident CHD regardless of hsCRP levels.
Among participants with established coronary heart disease at baseline, Lp(a) was associated with recurrent CHD events only in those with residual inflammatory risk marked by elevated hsCRP.

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Implication

Demonstrates that lipoprotein(a) requires high C-reactive protein to predict recurrent heart disease in existing patients, suggesting tailored selection for therapies.

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Cite This Study

Arnold et al. (2024) studied this question.

synapsesocial.com/papers/69eee05fb65c86b636037fc6 https://doi.org/10.1093/eurheartj/ehad867

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C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease: the BiomarCaRE project

Key Points

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Implication

Abstract

Discussion

Cite This Study

C-reactive protein modifies lipoprotein(a)-related risk for coronary heart disease: the BiomarCaRE project

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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