A Case of Anaphylactic Shock Induced by Nafamostat Mesylate During Hemodialysis with Elevated Serum Tryptase Levels

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Key Points

To investigate a case of anaphylactic shock induced by nafamostat mesylate during hemodialysis and examine the diagnostic utility of serum tryptase levels.
Case report of a 72-year-old male experiencing anaphylactic shock after hemodialysis using nafamostat mesylate.
Performed prick tests and blood tests to evaluate allergic reactions and measure serum tryptase levels.
Discontinued nafamostat mesylate during hemodialysis to monitor symptom recurrence.
The patient exhibited elevated serum tryptase levels during the incident, confirming anaphylactic shock.
Prick test was positive for nafamostat mesylate, establishing the diagnosis.
No symptom recurrence was noted after discontinuation of nafamostat mesylate during hemodialysis.

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Case report describes anaphylactic shock from nafamostat mesylate in a patient undergoing hemodialysis, indicating the need for careful monitoring.

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KOIKE et al. (2026) studied this question.

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