Key result
Levetiracetam linked to effective management of adult-onset epilepsy in a Landau-Kleffner syndrome case.
Why the study?
Landau-Kleffner syndrome presenting with adult-onset epilepsy is rare, with limited literature regarding its clinical presentation, diagnosis, and treatment options.
Case Report (n=1)
This case report highlights the rare presentation of Landau-Kleffner syndrome with adult-onset epilepsy and the potential effectiveness of levetiracetam.
Supports considering LKS in adult epilepsy with regression; leaves open incidence, mechanisms, and evidence-based therapies.
This case report describes Landau–Kleffner syndrome (LKS) with adult-onset epilepsy in a 33-year-old man with preexisting developmental delay. We outline the clinical presentation, including language regression and seizures, and address the diagnostic challenges. The case highlights the importance of considering LKS in case of adult-onset epilepsy and underscores the critical role of electroencephalography, particularly the presence of continuous spike-wave activity during sleep. We also review the treatment options of LKS with adult-onset epilepsy, with the focus on the effectiveness of levetiracetam. An atypical finding of right hippocampal sclerosis on brain magnetic resonance imaging is also noted. This case contributes to the limited literature on LKS with adult-onset epilepsy and emphasizes the need for further research.
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Hsu et al. (2026) conducted a case report in Landau-Kleffner syndrome with adult-onset epilepsy (n=1). Levetiracetam was evaluated. A 33-year-old man with developmental delay presented with adult-onset epilepsy and Landau-Kleffner syndrome, demonstrating the diagnostic value of EEG and the effectiveness of levetiracetam.
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