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The research aims to explore the expression of cell-cycle-dependent genes in human lymphocytes stimulated by phytohemagglutinin.

April 27, 2026Open Access

Expression of cell-cycle-dependent genes in phytohemagglutinin-stimulated human lymphocytes.

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The research aims to explore the expression of cell-cycle-dependent genes in human lymphocytes stimulated by phytohemagglutinin.
Investigated gene expression in human peripheral blood mononuclear cells (PBMC) stimulated by phytohemagglutinin (PHA)
Analyzed genes induced in different culture conditions, including partial depletion of accessory cells
Assessed time course of RNA levels for specific genes during lymphocyte activation.
Gene 2F1 and IL-2 receptor were induced by PHA in partially depleted cultures where cells grew but didn't enter S phase.
c-myc, 4F1, JE-3, and KC-1 genes were expressed only in complete PBMC cultures after PHA stimulation.
Findings indicate a dissociation between cell size increase and DNA replication during cell-cycle progression.

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Randomized trial investigates gene expression in lymphocytes, suggesting markers for cell-cycle progression.

L et al. (1985) studied this question.

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