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The study aims to explore the role of HHV-6 infection in multiple sclerosis by measuring antibody levels and viral sequences.

April 27, 2026Open Access

Human Herpesvirus-6 and Multiple-Sclerosis - Survey of Anti-HHV-6 Antibodies by Immunofluorescence Analysis and of Viral Sequences by Polymerase Chain-Reaction

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Randomized trial investigates anti-HHV-6 antibodies in multiple sclerosis, suggesting immune impairment links.

The study aims to explore the role of HHV-6 infection in multiple sclerosis by measuring antibody levels and viral sequences.
Immunofluorescence analysis of sera from 126 MS patients and 500 normal controls.
Polymerase chain reaction (PCR) assay of PBMC DNAs from 31 MS patients and 24 normal subjects.
Southern blot analysis of viral sequences in MS patient and control samples.
Anti-HHV-6 antibody titres were significantly higher in MS patients compared to normal controls.
PCR assay showed positive results for viral sequences in one MS patient and one normal control.
Southern blot analysis indicated a high level of viral sequences specifically in the MS patient, suggesting immune impairment rather than reactivation.

P et al. (1993) studied this question.

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