Why the study?
Human endogenous retrovirus W family envelope proteins have been repeatedly associated with MS, but their expression levels in different MS forms and relationships with EBV and HHV-6A/B needed exploration.
Population
101 MS patients (relapsing and progressive forms) and 37 healthy donors
Comparison
Relapsing MS vs progressive MS vs healthy donors
Design
Cross-sectional comparative study
Authors
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May link HHV-6 to HERV-W in MS; leaves open causality and any therapeutic implications.
pHERV-W ENV expression is elevated in multiple sclerosis and correlates with anti-HHV-6A/B antibodies, suggesting a potential role in MS pathogenesis and viral transactivation.
Pérez‐Pérez et al. (2021) studied this question.
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