Tandem one-pot synthesis demonstrates efficient production of triazole-fused quinazolinones, indicating new methods in organic chemistry.
The Front Cover shows a copper-catalyzed tandem strategy that enables the efficient synthesis of triazole-fused quinazolinones through a multicomponent reaction of 2-bromophenyl quinazolinones, sodium azide, and terminal alkynes. Integrating CuAAC and Ulmann-type C–N coupling under mild, ligand-free conditions, this method yields diverse polycyclic N-heterocycles with broad substrate scope. More information can be found in the Research Article by M. Alla and co-workers (DOI: 10.1002/ejoc.202501064).
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Kandula et al. (2026) studied this question.
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