Why the study?
What are the predictors of early and late mortality after TAVI in patients with severe aortic stenosis?
What are the predictors of early and late mortality after TAVI in patients with severe aortic stenosis?
Early mortality after TAVI is primarily driven by procedural complications, whereas late mortality up to 1 year is driven by baseline comorbidities and significant paravalvular leak.
May inform periprocedural risk mitigation to curb early TAVI mortality; leaves open whether comorbidity management or leak reduction improves late survival.
Benefit of TAVI with the CoreValve Revalving System is maintained over time up to 1 year, with acceptable mortality rates at various time points. Although procedural complications are strongly associated with early mortality at 30 days, comorbidities and postprocedural paravalvular aortic regurgitation ≥ 2+ mainly impact late outcomes between 30 days and 1 year.
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Tamburino et al. (2011) studied this question.
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