Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity.
Population
27 subjects: 12 patients with cardiac failure and 15 subjects without heart failure.
Design
Case-control
Authors
Discussion
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Member takes
Implication
Supports sympathetic overdrive in heart failure; extends regional spillover data but leaves open therapeutic targeting.
Structured PICO
P
Population
27 subjects: 12 patients with cardiac failure (left ventricular ejection fraction 10% to 39%) and 15 subjects without heart failure.
C
Comparator
15 subjects without heart failure
O
Outcome
Mean arterial plasma norepinephrine concentration and regional norepinephrine spillover (cardiac, renal, lungs)surrogate
Patients with congestive heart failure exhibit markedly increased overall, cardiac, and renal sympathetic nervous activity, highlighting important pathophysiologic mechanisms.
Cite This Study
Hasking et al. (1986) studied this question.