Why the study?
Does plasma endothelin-1 correlate with the extent of pulmonary hypertension in patients with chronic congestive heart failure?
Does plasma endothelin-1 correlate with the extent of pulmonary hypertension in patients with chronic congestive heart failure?
Plasma endothelin-1 levels correlate with the severity of pulmonary hypertension in patients with chronic congestive heart failure, suggesting a potential role as a biomarker or mediator.
Hypothesis-generating in CHF with PH; prospective studies needed before biomarker or therapeutic use.
Elevated immunoreactive endothelin-1 specifically correlated with the extent of pulmonary hypertension in congestive heart failure patients. Whether endothelin-1 is a regional mediator of pulmonary hypertension or a marker for its occurrence requires additional evaluation.
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Cody et al. (1992) studied this question.
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