January 21, 1997Circulation245 citations
View Full PaperTNK-Tissue Plasminogen Activator in Acute Myocardial Infarction
Structured PICO
P
Population
Patients with acute myocardial infarction
I
Intervention
TNK-Tissue Plasminogen Activator (tenecteplase) administered as a single bolus
TNK-TPA is a promising fibrin-specific thrombolytic agent for acute myocardial infarction that allows for single bolus administration.
Abstract
TNK-TPA has a prolonged half-life so it can be administered as a single bolus. TNK-TPA appears to be very fibrin specific, and the initial patency and safety profiles are encouraging. Further study of this new thrombolytic agent is ongoing.