January 21, 1997Circulation
TNK-Tissue Plasminogen Activator in Acute Myocardial Infarction
Population
Patients with acute myocardial infarction
Design
Review
Authors
Discussion
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Member takes
Implication
May support single-bolus thrombolysis in AMI; leaves open comparative efficacy versus tPA pending RCTs.
Structured PICO
P
Population
Patients with acute myocardial infarction
I
Intervention
TNK-Tissue Plasminogen Activator (tenecteplase) administered as a single bolus
TNK-TPA is a promising fibrin-specific thrombolytic agent for acute myocardial infarction that allows for single bolus administration.
Cite This Study
Cannon et al. (1997) studied this question.