January 1, 1992American Journal of Hypertension
Reversal of Left Ventricular Hypertrophy in Hypertensive Patients
Why the study?
Do different classes of antihypertensive therapies reduce left ventricular mass in hypertensive patients?
Population
2,357 hypertensive patients from 109 studies, average age 49 years (range 30 to 71), 28% previously untreated.
Comparison
Antihypertensive pharmacologic therapy vs Comparison between different classes of…
Design
Meta-analysis
Authors
Discussion
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Implication
ACE inhibitors may be prioritized for LVH regression; extends class-comparison evidence with quantified LVM reductions.
Structured PICO
Do different classes of antihypertensive therapies reduce left ventricular mass in hypertensive patients?
P
Population
2,357 hypertensive patients from 109 studies, average age 49 years (range 30 to 71), 28% previously untreated.
I
Intervention
Antihypertensive pharmacologic therapy (ACE inhibitors, beta-blockers, calcium antagonists, or diuretics)
C
Comparator
Comparison between different classes of first-line antihypertensive therapies
O
Outcome
Left ventricular mass (LVM) measured by echocardiographysurrogate
ACE inhibitors appear more effective than other first-line antihypertensive therapies in reversing left ventricular hypertrophy, primarily by reducing wall thickness.
Cite This Study
Dahlöf et al. (1992) studied this question.