December 1, 1998Circulation
Low Incidence of Myocardial Recovery After Left Ventricular Assist Device Implantation in Patients With Chronic Heart Failure
Why the study?
Does LVAD support lead to significant myocardial recovery allowing for device explantation in patients with end-stage congestive heart failure?
Population
150 patients with end-stage congestive heart failure receiving a mechanical bridge to transplantation at a…
Design
Cohort
Follow-up
Approximately 3 months after device implantation for…
Authors
Discussion
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Implication
Recovery allowing LVAD explantation remains rare in advanced HF; hypothesis-generating for protocols to identify candidates.
Structured PICO
Does LVAD support lead to significant myocardial recovery allowing for device explantation in patients with end-stage congestive heart failure?
P
Population
150 patients with end-stage congestive heart failure receiving a mechanical bridge to transplantation (left ventricular assist device) at a single center, comprising a retrospective cohort (n=111) and a prospective cohort (n=39).
I
Intervention
Left ventricular assist device (LVAD) support (Thermo Cardiosystems vented electric device in the prospective cohort) with exercise testing and hemodynamic monitoring to identify explant candidates.
O
Outcome
Incidence of successful device explantation due to myocardial recovery.hard clinical
Significant myocardial recovery after LVAD therapy in end-stage heart failure is rare, but exercise testing with reduced device support may help identify the small percentage of candidates suitable for device explantation.
Cite This Study
Mancini et al. (1998) studied this question.