Key result
Prolonged left ventricular support with an LVAD in men with end-stage cardiomyopathy led to a significant decrease in stretched myocardial fibers, increased fiber diameter, and slight fibrosis.
Why the study?
Does prolonged left ventricular unloading with an LVAD alter myocardial histopathology in patients with end-stage cardiomyopathy?
Population
8 men with end-stage cardiomyopathy, mean age 40.8 years, with significantly dilated left ventricular…
Comparison
Prolonged left ventricular unloading with… vs Baseline myocardial tissue.
Design
Case_series
Follow-up
average 79.6 days (range, 31-136 days)
Authors
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Histologic changes with prolonged LVAD support are hypothesis-generating; larger prospective studies needed before clinical adoption.
Observational (n=8)
Does prolonged left ventricular unloading with an LVAD alter myocardial histopathology in patients with end-stage cardiomyopathy?
Prolonged LVAD support in end-stage cardiomyopathy leads to histopathologic changes including decreased stretched fibers and increased fiber diameter, which correlates with improved native ventricular function.
Scheinin et al. (1992) conducted an observational in End-stage cardiomyopathy (n=8). Prolonged left ventricular support (LVAD) vs. Pre-LVAD support (baseline apical core specimens) was evaluated on Myocardial histopathology changes. Prolonged left ventricular support with an LVAD in men with end-stage cardiomyopathy led to a significant decrease in stretched myocardial fibers, increased fiber diameter, and slight fibrosis.
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