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June 4, 2003Circulation499 citationsOpen Access

Interferon-β Treatment Eliminates Cardiotropic Viruses and Improves Left Ventricular Function in Patients With Myocardial Persistence of Viral Genomes and Left Ventricular Dysfunction

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UKUwe KühlMPMatthias PauschingerPSPeter Schwimmbeck

Structured PICO

Does interferon-beta treatment eliminate viral genomes and improve LV function in patients with myocardial enteroviral or adenoviral persistence and LV dysfunction?

P
Population
22 patients with myocardial enteroviral or adenoviral persistence and left ventricular (LV) dysfunction
I
Intervention
Interferon-beta (IFN-beta) treatment for 6 months
O
Outcome
Elimination of viral genomes and improvement in LV functionsurrogate

A 6-month course of interferon-beta safely eliminated viral genomes and improved left ventricular function in patients with viral persistence and LV dysfunction.

Abstract

A 6 months, IFN-beta treatment was safe in patients with myocardial enteroviral or adenoviral persistence and LV dysfunction and resulted in elimination of viral genomes (22 of 22 patients) and improved LV function (15 of 22 patients).

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Cite This Study

Kühl et al. (2003) studied this question.

synapsesocial.com/papers/69effb364f6a06657c21e377https://doi.org/10.1161/01.cir.0000072766.67150.51
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