Why the study?
Does global left ventricular afterload impact left ventricular function in asymptomatic severe aortic stenosis?
Population
Asymptomatic patients with severe aortic stenosis (AS)
Design
Cross-sectional
Authors
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Speckle-tracking may detect systolic impairment missed by LVEF in high-afterload AS; hypothesis-generating and requires prospective validation before practice change.
Does global left ventricular afterload impact left ventricular function in asymptomatic severe aortic stenosis?
In asymptomatic severe aortic stenosis, LV ejection fraction underestimates myocardial systolic impairment, highlighting the value of speckle-tracking echocardiography to detect intrinsic dysfunction related to increased global LV afterload.
Lancellotti et al. (2010) studied this question.
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