July 25, 2001JAMA
Albuminuria and Risk of Cardiovascular Events, Death, and Heart Failure in Diabetic and Nondiabetic Individuals
Why the study?
Is any degree of albuminuria a risk factor for cardiovascular events, death, and heart failure in individuals with or without diabetes?
Population
Individuals with or without diabetes mellitus (DM)
Comparison
Albuminuria vs Lower levels of albuminuria or no albuminuria
Design
Cohort
Authors
Discussion
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Member takes
Implication
May support ACR in CV risk assessment below microalbuminuria; extends continuous association to nondiabetics but leaves practice change open.
Structured PICO
Is any degree of albuminuria a risk factor for cardiovascular events, death, and heart failure in individuals with or without diabetes?
P
Population
Individuals with or without diabetes mellitus (DM)
I
Intervention
Albuminuria (measured by albumin-to-creatinine ratio [ACR])
C
Comparator
Lower levels of albuminuria or no albuminuria
O
Outcome
Cardiovascular events, death, and heart failurehard clinical
Any degree of albuminuria, even below the traditional microalbuminuria cutoff, is a risk factor for cardiovascular events in both diabetic and nondiabetic individuals.
Cite This Study
Hertzel C. Gerstein (2001) studied this question.