Key result
Neurocardiogenic syndromes drive post-stroke CV complications via brain-heart interactions, causing over 1.5 million deaths worldwide.
Why the study?
Neurocardiogenic syndromes cause over 1.5 million deaths worldwide and extensive cardiovascular morbidity, with multiple pathophysiological mechanisms identified over the last decade that could serve as targets for novel therapies.
Hypothesis-generating for post-stroke cardiac protection; leaves open randomized trials before clinical adoption.
Over 1.5 million deaths worldwide are caused by neurocardiogenic syndromes. Furthermore, the consequences of deleterious brain-heart interactions are not limited to fatal complications. Cardiac arrhythmias, heart failure, and nonfatal coronary syndromes are also common. The brain-heart axis is implicated in post-stroke cardiovascular complications known as the stroke-heart syndrome, sudden cardiac death, and Takotsubo syndrome, among other neurocardiogenic syndromes. Multiple pathophysiological mechanisms with the potential to be targeted with novel therapies have been identified in the last decade. In the present state-of-the-art review, we describe recent advances in the understanding of anatomical and functional aspects of the brain-heart axis, cardiovascular complications after stroke, and a comprehensive pathophysiological model of stroke-induced cardiac injury.
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Sposato et al. (2020) conducted a review in Post-stroke cardiovascular complications and neurogenic cardiac injury. Neurocardiogenic syndromes, which cause over 1.5 million deaths worldwide, involve complex brain-heart interactions that lead to post-stroke cardiovascular complications and cardiac injury.
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