What question did this study set out to answer?

Investigate adipocyte subtypes, developmental trajectories, and cell-cell communication patterns to explain functional differences between human subcutaneous and visceral adipose tissues.

January 24, 2025Nature GeneticsOpen Access

Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns

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Why the study?

Human adipose depots are functionally distinct, yet recent snRNA-seq analyses largely uncovered overlapping cell-type landscapes, leaving a depot similarity-difference gap.

Population

Five human subcutaneous and ten visceral adipose tissue samples (27,665 adipocyte nuclei)

Comparison

Subcutaneous vs visceral adipose tissue

Design

Single-nucleus RNA sequencing study

Authors

OLOr LazarescuBen-Gurion University of the Negev MZMaya Ziv-AgamBen-Gurion University of the Negev YHYulia HaimBen-Gurion University of the Negev

Discussion

Member takes

Implication

Adipose depot-specific adipocyte mapping may guide CV risk models; leaves open clinical translation pending functional validation.

Key Points

Investigate adipocyte subtypes, developmental trajectories, and cell-cell communication patterns to explain functional differences between human subcutaneous and visceral adipose tissues.
Performed single-nucleus RNA sequencing (snRNA-seq) on 5 human subcutaneous and 10 human visceral adipose tissue samples, analyzing 27,665 adipocyte nuclei.
Conducted pseudo-temporal developmental trajectory modeling and intercellular communication network analyses across fat depots.
Most adipocytes displayed a classical profile enriched in lipid metabolism pathways, while nonclassical subtypes were enriched in immune signaling, extracellular matrix deposition, angiogenesis, and mitochondrial activity.
Pseudo-temporal trajectory mapping revealed that progenitor cells differentiate into classical adipocytes through nonclassical intermediate states, driven by the loss rather than gain of specialized functions.
Intercellular communication pathways matched the differing inflammatory baselines between subcutaneous and visceral depots.

Cite This Study

Lazarescu et al. (2025) studied this question.

synapsesocial.com/papers/69f14a932811130d0cde1e3e https://doi.org/10.1038/s41588-024-02048-3

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Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns

Discussion

Member takes

Implication

Key Points

Cite This Study

Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns

Discussion

Member takes

Implication

Key Points

Cite This Study

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