Key result
Subacute post-MI NT-proBNP predicts poor 6-week outcomes, explaining ~18% of outcome variance.
Why the study?
The temporal pattern and optimal timing of plasma N-terminal pro-brain natriuretic peptide sampling for identifying impaired left ventricular systolic function after acute myocardial infarction were unclear.
Does the temporal pattern of plasma N-terminal proBNP predict left ventricular systolic dysfunction and poor outcome following acute myocardial infarction?
Population
60 patients following acute myocardial infarction
Comparison
Plasma N-terminal pro-brain natriuretic peptide levels at multiple time points
Design
Observational cohort study
Follow-up
6 weeks
Authors
Loading...
May refine post-MI risk stratification with later sampling; extends biomarker timing data but remains hypothesis-generating.
Observational (n=60)
Does the temporal pattern of plasma N-terminal proBNP predict left ventricular systolic dysfunction and poor outcome following acute myocardial infarction?
Effect estimate: R2 17.7%
p-value: p=0.005
Plasma NT-proBNP measured later in hospitalization (73-120 h) after acute myocardial infarction is a strong independent predictor of subsequent left ventricular systolic dysfunction and poor clinical outcome.
Suneel Talwar (2000) conducted an observational in Acute myocardial infarction (n=60). Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) was evaluated on Poor outcome (WMI-2 <= 1.2 or death by 6 weeks) (R2 17.7%, p=0.005). Plasma N-terminal pro-brain natriuretic peptide measured at 73-120 hours post-myocardial infarction independently predicted poor outcome at 6 weeks (R2=17.7%, P=0.005).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: