What question did this study set out to answer?

This research aims to evaluate the effects of intracoronary nitroglycerin and streptokinase on acute myocardial infarction.

October 1, 1979Clinical Cardiology

Acute myocardial infarction: Intracoronary application of nitroglycerin and streptokinase

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Why the study?

Does intracoronary nitroglycerin and streptokinase improve coronary patency in patients with acute myocardial infarction?

Population

5 patients with acute myocardial infarction

Design

Case_series

Follow-up

acute

Authors

KRK.Peter RentropColumbia University Irving Medical Center HBH. BlankeHeinrich Heine University Düsseldorf KKK. R. KarschUniversitätsklinikum Tübingen

Discussion

Member takes

Implication

May support intracoronary thrombolysis in select AMI; hypothesis-generating and requires randomized confirmation.

Key Points

This research aims to evaluate the effects of intracoronary nitroglycerin and streptokinase on acute myocardial infarction.
Five patients with acute myocardial infarction were treated with both intracoronary nitroglycerin and streptokinase.
Transluminal recanalization was performed in one patient using a guide wire.
Streptokinase was infused at a dose of 1,000-2,000 U/min for 15-60 minutes.
Intracoronary NTG improved distal filling in subtotally occluded arteries in two patients.
Success in transluminal recanalization resulted in patency of a previously occluded artery in one patient.
Intracoronary streptokinase led to long-term reduction of narrowing in three patients, improving symptoms and ECG changes.

Structured PICO

Does intracoronary nitroglycerin and streptokinase improve coronary patency in patients with acute myocardial infarction?

Population

5 patients with acute myocardial infarction

Intervention

Intracoronary nitroglycerin (NTG) followed by intracoronary streptokinase (1,000-2,000 U/min for 15-60 min); transluminal recanalization in one patient

Outcome

Coronary patency/recanalization and alleviation of symptomssurrogate

Intracoronary administration of nitroglycerin and streptokinase can achieve coronary recanalization and symptom relief in acute myocardial infarction.

Cite This Study

Rentrop et al. (1979) studied this question.

synapsesocial.com/papers/69f14b292811130d0cde206b https://doi.org/10.1002/clc.4960020507

Topics

Coronary CT angiography

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Acute myocardial infarction: Intracoronary application of nitroglycerin and streptokinase

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Acute myocardial infarction: Intracoronary application of nitroglycerin and streptokinase

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider