Why the study?
Does coronary artery disease progression on angiography predict future clinical coronary events in nonsmoking men with previous CABG?
Population
162 nonsmoking, 40- to 59-year-old men with previous coronary artery bypass graft (CABG) surgery
Comparison
Colestipol/niacin plus diet vs Placebo plus diet
Design
RCT, Randomized
Follow-up
average of 7 years (range, 6.3 months to 10 years)
Authors
Loading...
Supports angiographic progression as valid surrogate for clinical events post-CABG; extends evidence justifying shorter antiatherosclerotic trials.
Does coronary artery disease progression on angiography predict future clinical coronary events in nonsmoking men with previous CABG?
Angiographic progression of coronary artery disease is a valid surrogate endpoint that significantly predicts future clinical coronary events, justifying the use of shorter trials for antiatherosclerotic agents.
Azen et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: