August 16, 2005Circulation
Increased Cardiac Expression of Tissue Inhibitor of Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-2 Is Related to Cardiac Fibrosis and Dysfunction in the Chronic Pressure-Overloaded Human Heart
Population
65 patients, comprising 36 with isolated aortic stenosis and 29 control patients without left ventricular…
Design
Case-control
Authors
Discussion
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Implication
May link TIMP upregulation to fibrosis in AS; leaves open whether targeting TIMPs alters outcomes in pressure overload.
Structured PICO
P
Population
65 patients, comprising 36 with isolated aortic stenosis (AS) and 29 control patients without left ventricular (LV) hypertrophy.
C
Comparator
Control patients without LV hypertrophy
O
Outcome
Cardiac mRNA expression of TIMP-1 and TIMP-2, and its relationship to interstitial fibrosis and diastolic dysfunctionsurrogate
Increased cardiac expression of TIMP-1 and TIMP-2 is associated with interstitial fibrosis and diastolic dysfunction in patients with chronic pressure overload from aortic stenosis.
Cite This Study
Heymans et al. (2005) studied this question.