Why the study?
Does brain death increase interstitial myocardial norepinephrine release in anesthetized pigs?
Population
Anesthetized pigs
Comparison
Induction of brain death and measurement of… vs Baseline levels before brain death
Design
Preclinical
Follow-up
40 minutes post-brain death
Authors
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May implicate local norepinephrine in donor heart injury; leaves open translation to human allograft preservation.
Does brain death increase interstitial myocardial norepinephrine release in anesthetized pigs?
Brain death induces a dramatic, biphasic increase in local cardiac norepinephrine release that can be effectively measured using cardiac microdialysis, potentially explaining brain death-associated myocardial damage.
Mertès et al. (1994) studied this question.