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Investigate age and birth cohort effects on influenza A hospitalization rates in the US.

Effects of age and birth cohort on influenza A virus subtype-specific hospitalization rates, United States 2010-2025

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Investigate age and birth cohort effects on influenza A hospitalization rates in the US.
Analyzed hospitalization rates for influenza A subtypes from 2010 to 2025
Utilized U.S. population-based surveillance data
Compared rates between A(H1N1)pdm09 and A(H3N2) infections by age group and birth year
Older adults show higher hospitalization rates for influenza during specific seasons
Pre-1945 birth cohorts display partial protection against A(H1N1)pdm09
Hospitalization patterns indicate increasing risks for future influenza seasons

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Analysis shows fluctuations in influenza season hospitalization rates by birth cohort, suggesting patterns of risk in older adults.

O’Halloran et al. (2026) studied this question.

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