Oxidative coupling finds new applications in bioconjugation of phenols, suggesting enhanced reactivity.
The bioconjugation of unmodified native peptides, in particular at their tyrosine units with the dehydrogenative phenochalcogenazination reaction, has attracted much attention lately due to potential click type applications. In our quest to bring this oxidative coupling concept beyond phenothiazines and its derivatives, we report herein the case of sulfenamides and their mild O 2 ‐mediated Cu‐catalyzed dehydrogenative sulfilimination of diverse bioactive phenols.
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Xiao et al. (2026) studied this question.
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