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January 1, 2026Toukeibu GanOpen Access

Two cases of proton beam therapy combined with chemotherapy for head and neck small cell carcinoma

Funa Arai Gaku Takano Daisuke Kawakita Hiromitsu Iwata Takuma Matoba Kiyoshi Minohara Kazuyuki Nakai Sho Iwaki Hiroshi Tsuge Koji Tsukamoto Tomota Kamida Hiroyuki Ogino Shinichi Iwasaki

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Key Points

This report aims to explore the efficacy of proton beam therapy combined with chemotherapy in treating head and neck small cell carcinoma.
Described two clinical cases of patients diagnosed with head and neck small cell carcinoma.
Administered proton beam therapy alongside chemotherapy for treatment.
Monitored treatment outcomes and responses to the combination therapy.
Both patients exhibited positive responses to treatment with noticeable tumor reduction.
No significant adverse effects were reported, indicating tolerability of the combined treatment.

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Implication

Case report demonstrates the effect of combination therapy in head and neck small cell carcinoma, suggesting potential benefits.

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Cite This Study

Arai et al. (2026) studied this question.

synapsesocial.com/papers/69f19f16edf4b468248061fa https://doi.org/10.5981/jjhnc.52.26

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Proton Radiation Therapy for Local Control in a Case of Osteosarcoma of the Neckcase_report · 2016 · 3 citations
2Early clinical outcomes of helical tomotherapy/intensity‐modulated proton therapy combination in nasopharynx cancerCohort Study · 2019 · 23 citations
3Salvage Proton Therapy Re-Irradiation in Recurrent Head and Neck Cancer: Outcomes and Adverse Events by Re-Irradiated Target SiteCohort Study · 2026
4Transmission beam planning for improved robustness and efficiency in proton therapy for head and neck cancerOriginal Research · 2025 · 1 citations
5Current Status and Future Directions of Proton Therapy for Head and Neck Carcinoma2024 · 18 citations

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