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April 27, 2026Autophagy

The nuclear receptor ESRRA is a crucial regulator of acute kidney injury through inhibition of the lipophagy-ferroptosis axis

Yuanting Yang Xuying Zhu Yan Fang Jialin Li Xinghua Shao S X Li Haijiao Jin Chaojun Qi Zhenyuan Li Leyi Gu Shan Mou Q N Lin Zhaohui Ni

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Key Points

To investigate the role of the nuclear receptor ESRRA in the regulation of acute kidney injury (AKI) and its mechanisms.
Examined ESRRA expression and AKT-MTOR signaling pathway activation in renal tubular epithelial cells.
Assessed the impact of RAB7 mediated lipophagy on AKI progression.
Activation of ESRRA enhances AKT-MTOR pathway, suppressing RAB7 mediated lipophagy.
Inhibition of lipophagy reduces ferroptosis, thus attenuating AKI.

Implication

Demonstrates ESRRA's role in regulating acute kidney injury, indicating its potential therapeutic implications.

Discussion

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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/69f19f9cedf4b46824806608 https://doi.org/10.1080/15548627.2026.2665391

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