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April 29, 2026International Journal of Food Science & TechnologyOpen Access

Chemical Characteristics and Antidepressant Mechanism of Fresh and Stir-fried Ziziphi Spinosae Semen in Chronic Unpredictable Mild Stress Rats: Effects on Neurotransmitters, Inflammation and Gut Microbiota

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Authors

YFYurou FengYZYuan ZhangJLJing Lian

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Overview

Randomized trial investigates the antidepressant effects of raw and stir-fried Ziziphi Spinosae Semen in CUMS rats, highlighting implications for treatment development.

Key Points

  • The aim is to understand the antidepressant mechanisms and chemical properties of raw and stir-fried Ziziphi Spinosae Semen in rats exposed to chronic stress.
  • 60 rats subjected to chronic unpredictable mild stress for 21 days
  • Behavioral assessments including open field test and forced swim test
  • ELISA and gene sequencing techniques applied to analyze neurotransmitters, inflammation, and gut microbiota
  • Both treatments improved exploratory behavior (P<0.01) and reduced immobility time (P<0.01)
  • ZSS and FZSS regulated HPA hormone levels and reduced pro-inflammatory cytokines
  • FZSS showed enhanced effects on BDNF-TrkB-CREB signaling and ERK1/2 phosphorylation in the hippocampus

Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/69f19fd5edf4b468248068cfhttps://doi.org/10.1093/ijfood/vvag079
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