Synthesis, anticancer activity, and molecular docking studies of some maleimide derivatives

Mashooq A. Bhat; Mohamed A. Al‐Omar; Ahmed H. Bakheit; Abdullah Al-Dhfyan

doi:10.1039/d6nj00004e

January 1, 2026New Journal of Chemistry

Synthesis, anticancer activity, and molecular docking studies of some maleimide derivatives

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Key Points

The study aims to evaluate the synthesis and anticancer properties of maleimide derivatives against specific cancer cell lines.
Synthesis of 4-(2,5-dioxo-2,5-dihydro-1 H -pyrrol-1-yl)-N′-[(substituted phenyl)methylidene]benzohydrazides (BF 1–12)
In vitro screening against K562 and KG-1 cancer cell lines
BF 1–12 showed varying levels of anticancer activity against K562 and KG-1 cell lines.
Specific maleimide derivatives demonstrated significant inhibition of cancer cell growth.
Further molecular docking studies indicated strong binding affinities for the synthesized compounds.

Implication

Shows anticancer activity of maleimide derivatives in K562 and KG-1 cancer cells, suggesting potential therapeutic applications.

Abstract

A series of 4-(2,5-dioxo-2,5-dihydro-1 H -pyrrol-1-yl)- N ′-[(substituted phenyl)methylidene]benzohydrazides ( BF 1–12 ) were synthesized and screened for in vitro anticancer activity against K562 and KG-1 cancer cell lines.

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Cite This Study

Bhat et al. (2026) studied this question.

synapsesocial.com/papers/69f19ff5edf4b46824806aa2 https://doi.org/10.1039/d6nj00004e

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Synthesis, anticancer activity, and molecular docking studies of some maleimide derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis, anticancer activity, and molecular docking studies of some maleimide derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

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