First tetrametallic 19-nuclear CeIII–ScIII–WVI–SbIII cluster-incorporated polyoxometalate for electrochemical biosensing of CYFRA21-1

Jiaxin Li; Zhigang Tang; Yu Liu; Lijuan Chen; Junwei Zhao

doi:10.1039/d6qi00653a

January 1, 2026Inorganic Chemistry Frontiers

First tetrametallic 19-nuclear CeIII–ScIII–WVI–SbIII cluster-incorporated polyoxometalate for electrochemical biosensing of CYFRA21-1

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Key Points

The research aims to develop a novel tetrametallic cluster-integrated polyoxometalate for the detection of the lung cancer biomarker CYFRA21-1.
Developed a novel tetrametallic cluster incorporating CeIII, ScIII, WVI, and SbIII within a polyoxometalate framework.
Utilized electrochemical techniques for biosensing assessment of CYFRA21-1 levels in serum samples.
Showed a significant increase in sensitivity for the detection of CYFRA21-1 compared to traditional methods.
Achieved a detection limit of 0.01 ng/mL, enhancing early diagnosis potential.

Implication

Demonstrates enhanced electrochemical biosensing for lung cancer biomarker in CYFRA21-1, suggesting improved early detection methods.

Abstract

Early detection of lung cancer is pivotal for enhancing patient survival rates, wherein cytokeratin fragment antigen 21-1 (CYFRA21-1) serves as a pivotal serum biomarker for clinical diagnosis. Nevertheless, early and...

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69f1a033edf4b46824806e08 https://doi.org/10.1039/d6qi00653a

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First tetrametallic 19-nuclear CeIII–ScIII–WVI–SbIII cluster-incorporated polyoxometalate for electrochemical biosensing of CYFRA21-1

Key Points

Implication

Abstract

Discussion

Cite This Study

First tetrametallic 19-nuclear CeIII–ScIII–WVI–SbIII cluster-incorporated polyoxometalate for electrochemical biosensing of CYFRA21-1

Key Points

Implication

Abstract

Discussion

Cite This Study

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