What does this research mean for the field?

A novel, inexpensive, and label-free electrochemical immunosensor utilizing a g-C3N4/ZnO nanocomposite-modified disposable paper carbon electrode can sensitively and selectively detect the lung cancer biomarker CYFRA21-1 with a detection limit of 0.0281 ng/mL. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Develop a low-cost, disposable, and label-free electrochemical immunosensor based on g-C3N4/ZnO nanocomposites to sensitively detect the non-small cell lung cancer biomarker CYFRA21-1.

August 22, 2026Analytical Chemistry Letters

g-C 3 N 4 /ZnO Nanocomposite-modified disposable paper carbon electrode for label-free electrochemical immunodetection of lung cancer biomarker CYFRA21-1

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Authors

PRPooja Rahar SSSaravjeet Singh

Discussion

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Overview

In vitro experimental study demonstrates sensitive label-free CYFRA21-1 detection using nanocomposite-modified paper electrodes, indicating strong potential for low-cost point-of-care lung cancer...

Key Points

Develop a low-cost, disposable, and label-free electrochemical immunosensor based on g-C3N4/ZnO nanocomposites to sensitively detect the non-small cell lung cancer biomarker CYFRA21-1.
Fabricated disposable paper carbon electrodes modified with graphitic carbon nitride and zinc oxide (g-C3N4/ZnO) nanocomposites without noble metals or complex signal amplification.
Immobilized anti-CYFRA21-1 antibodies on the nanocomposite electrode and applied bovine serum albumin (BSA) blocking to ensure high selectivity for target antigen recognition.
Demonstrated a linear current response proportional to the logarithm of CYFRA21-1 concentration across a dynamic range of 0.1 to 100 ng/mL (R2 = 0.998).
Achieved a limit of detection of 0.0281 ng/mL under optimized sensing conditions.

Cite This Study

Rahar et al. (2026) studied this question.

synapsesocial.com/papers/6a895fd3ca7ade938187eafc https://doi.org/10.1080/22297928.2026.2696307

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August 22, 2026Analytical Chemistry Letters

g-C 3 N 4 /ZnO Nanocomposite-modified disposable paper carbon electrode for label-free electrochemical immunodetection of lung cancer biomarker CYFRA21-1

View Full Paper

Ask AI

Bookmark

Authors

PRPooja Rahar SSSaravjeet Singh

Discussion

Member takes

Overview

In vitro experimental study demonstrates sensitive label-free CYFRA21-1 detection using nanocomposite-modified paper electrodes, indicating strong potential for low-cost point-of-care lung cancer...

Key Points

Develop a low-cost, disposable, and label-free electrochemical immunosensor based on g-C3N4/ZnO nanocomposites to sensitively detect the non-small cell lung cancer biomarker CYFRA21-1.
Fabricated disposable paper carbon electrodes modified with graphitic carbon nitride and zinc oxide (g-C3N4/ZnO) nanocomposites without noble metals or complex signal amplification.
Immobilized anti-CYFRA21-1 antibodies on the nanocomposite electrode and applied bovine serum albumin (BSA) blocking to ensure high selectivity for target antigen recognition.
Demonstrated a linear current response proportional to the logarithm of CYFRA21-1 concentration across a dynamic range of 0.1 to 100 ng/mL (R2 = 0.998).
Achieved a limit of detection of 0.0281 ng/mL under optimized sensing conditions.

Cite This Study

Rahar et al. (2026) studied this question.

synapsesocial.com/papers/6a895fd3ca7ade938187eafc https://doi.org/10.1080/22297928.2026.2696307

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