Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 29, 2026Journal of the American College of Cardiology

Contribution of inadequate compensatory enlargement to development of human coronary artery stenosis: An in vivo intravascular ultrasound study

View Full Paper
Ask AI
Bookmark
Share

Why the study?

It was unclear in human coronary arteries whether inadequate compensatory enlargement contributes to the development of critical arterial stenosis.

Does inadequate compensatory enlargement contribute to the development of human coronary artery stenosis assessed by intravascular ultrasound?

Population

30 patients with 35 primary coronary artery lesions

Design

In vivo intravascular ultrasound study

Authors

TNToshihiko NishiokaWakayama Medical UniversityHLHuai LuoCedars-Sinai Medical CenterNENeal EiglerCedars-Sinai Smidt Heart Institute

Discussion

Loading...

Member takes

Implication

Vessel constriction contributes to coronary stenosis beyond plaque; leaves open integration of IVUS remodeling assessment into routine practice.

Structured PICO

Does inadequate compensatory enlargement contribute to the development of human coronary artery stenosis assessed by intravascular ultrasound?

P
Population
30 patients (19 men, 11 women; mean age 65 +/- 13 years) with 35 primary coronary artery lesions
I
Intervention
Intravascular ultrasound (IVUS) imaging
O
Outcome
Vessel cross-sectional area, lumen area, and wall area at the lesion site and reference sites to determine compensatory enlargementsurrogate

Inadequate compensatory enlargement (relative vessel constriction) contributes significantly to lumen area reduction in about a quarter of primary coronary artery lesions.

Cite This Study

Nishioka et al. (1996) studied this question.

synapsesocial.com/papers/69f1ccfea53d347ef6df0868https://doi.org/10.1016/0735-1097(96)00071-x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Focal compensatory enlargement of human arteries in response to progressive atherosclerosis. In vivo documentation using intravascular ultrasound.1994 · 240 citations
  2. 2Compensatory carotid artery dilatation in early atherosclerosis.1994 · 95 citations
  3. 3Structural and hemodynamic response of peripheral arteries of macaque monkeys to atherogenic diet.1985 · 152 citations