Right Heart Adaptation to Pulmonary Arterial Hypertension
Key result
Review highlights RV pathobiology in PAH, detailing molecular mechanisms, functional assessment, and targeted therapies.
Why the study?
Survival in PAH is tied to RV function, but significant variability remains in RV adaptation to pulmonary load and the emerging concepts of right heart pathobiology require discussion.
Design
Review
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for RV-targeted therapy in PAH; prospective trials needed before clinical adoption.
PICO
P
Population
Pulmonary arterial hypertension
Cite This Study
Noordegraaf et al. (2013) conducted a review in Pulmonary arterial hypertension. A review of right heart pathobiology in pulmonary arterial hypertension highlights the molecular mechanisms of the failing right ventricle, assessment of RV function, and targeted RV therapy.