Why the study?
Does antiinflammatory therapy (methylprednisolone) reduce atrial conduction inhomogeneity and atrial fibrillation duration in a canine model of cardiac surgery?
Population
Normal mongrel canines (n=24)
Comparison
Lateral right atriotomy with antiinflammatory… vs Anesthesia alone (control group)
Design
Preclinical
Follow-up
3 days
Authors
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Antiinflammatory therapy mitigated post-atriotomy conduction inhomogeneity and AF in canines; leaves open translation to human cardiac surgery.
Does antiinflammatory therapy (methylprednisolone) reduce atrial conduction inhomogeneity and atrial fibrillation duration in a canine model of cardiac surgery?
In a canine model, atrial inflammation after cardiac surgery increases atrial conduction inhomogeneity and AF duration, which can be mitigated by antiinflammatory therapy.
Ishii et al. (2005) studied this question.
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