Risk Factors for Aborted Cardiac Arrest and Sudden Cardiac Death in Children With the Congenital Long-QT Syndrome
Why the study?
Does beta-blocker therapy reduce the risk of aborted cardiac arrest or sudden cardiac death in children with congenital long-QT syndrome?
Population
3015 children with congenital long-QT syndrome from the International LQTS Registry, followed from 1 through…
Comparison
Beta-blocker therapy vs No beta-blocker therapy
Design
Cohort
Follow-up
from 1 through 12 years of age
Authors
Discussion
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Member takes
Implication
May support beta-blocker consideration in pediatric long-QT syndrome; leaves open need for randomized confirmation.
Structured PICO
Does beta-blocker therapy reduce the risk of aborted cardiac arrest or sudden cardiac death in children with congenital long-QT syndrome?
P
Population
3015 children with congenital long-QT syndrome (LQTS) from the International LQTS Registry, followed from 1 through 12 years of age
I
Intervention
Beta-blocker therapy
C
Comparator
No beta-blocker therapy
O
Outcome
Aborted cardiac arrest or sudden cardiac deathhard clinical
In children with congenital long-QT syndrome, boys have a higher rate of fatal or near-fatal events than girls, with QTc > 500 ms and prior syncope as key risk factors, while beta-blocker therapy significantly reduces the risk of life-threatening events.
Cite This Study
Goldenberg et al. (2008) studied this question.