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Mutation locus may aid long-QT syndrome risk stratification alongside QTc and sex; leaves open prospective validation before practice change.
The locus of the causative mutation affects the clinical course of the long-QT syndrome and modulates the effects of the QTc and sex on clinical manifestations. We propose an approach to risk stratification based on these variables.
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Priori et al. (2003) studied this question.
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