November 15, 1995Circulation
ECG T-Wave Patterns in Genetically Distinct Forms of the Hereditary Long QT Syndrome
Why the study?
Do different genetic loci for long QT syndrome (chromosomes 3, 7, 11) result in distinct phenotypic ECG T-wave patterns?
Population
153 members of six families with long QT syndrome linked to markers on chromosomes 3, 7, and 11
Comparison
Long QT syndrome genotypes vs Unaffected family members and cross-genotype…
Design
Cohort
Authors
Discussion
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Member takes
Implication
May aid LQTS genotype identification via ECG; extends correlations but leaves open impact on diagnosis or risk stratification.
Structured PICO
Do different genetic loci for long QT syndrome (chromosomes 3, 7, 11) result in distinct phenotypic ECG T-wave patterns?
P
Population
153 members of six families with long QT syndrome linked to markers on chromosomes 3 (n = 47), 7 (n = 30), and 11 (n = 76)
I
Intervention
Long QT syndrome genotypes (mutations on chromosomes 3, 7, and 11)
C
Comparator
Unaffected family members and cross-genotype comparison
O
Outcome
Five quantitative ECG repolarization parameters (QTonset-c, QTpeak-c, QTc, Tduration-c, and Tamplitude)surrogate
Cite This Study
Moss et al. (1995) studied this question.