May 13, 2005Circulation ResearchOpen Access

Bidirectional Ventricular Tachycardia and Fibrillation Elicited in a Knock-In Mouse Model Carrier of a Mutation in the Cardiac Ryanodine Receptor

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Why the study?

Does the R4496C RyR2 mutation predispose mice to ventricular tachycardia upon adrenergic stimulation, and do beta-blockers prevent these arrhythmias?

Structured PICO

Does the R4496C RyR2 mutation predispose mice to ventricular tachycardia upon adrenergic stimulation, and do beta-blockers prevent these arrhythmias?

Population

47 mice, including wild-type (WT) and a conditional knock-in mouse model carrier of the R4496C mutation in the RyR2 gene (mouse equivalent to human R4497C CPVT mutation)

Intervention

Adrenergic stimulation via exercise stress testing followed by epinephrine administration, or epinephrine and caffeine administration, with or without propranolol pretreatment

Comparator

Wild-type mice receiving the same stimulation

Outcome

Development of ventricular tachycardia (VT)surrogate

The R4496C RyR2 mutation predisposes murine hearts to ventricular tachycardia upon adrenergic stimulation, and beta-blockers appear ineffective in preventing these arrhythmias in this model.

Discussion

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Implication

RyR(R4496C) mutation confers adrenergic VT susceptibility in mice; leaves open beta-blocker efficacy in human CPVT.

Cite This Study

Cerrone et al. (2005) studied this question.

synapsesocial.com/papers/69f29ce01b51e2fbf01872ac https://doi.org/10.1161/01.res.0000169067.51055.72

Topics

Ventricular arrhythmias

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Bidirectional Ventricular Tachycardia and Fibrillation Elicited in a Knock-In Mouse Model Carrier of a Mutation in the Cardiac Ryanodine Receptor

Structured PICO

Discussion

Implication

Cite This Study

Topics

Bidirectional Ventricular Tachycardia and Fibrillation Elicited in a Knock-In Mouse Model Carrier of a Mutation in the Cardiac Ryanodine Receptor

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider