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February 14, 2006CirculationOpen Access

Novel Speckle-Tracking Radial Strain From Routine Black-and-White Echocardiographic Images to Quantify Dyssynchrony and Predict Response to Cardiac Resynchronization Therapy

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Why the study?

Does speckle-tracking radial strain quantify dyssynchrony and predict response to cardiac resynchronization therapy in heart failure patients?

Population

74 subjects: 64 heart failure patients undergoing cardiac resynchronization therapy and 10 normal controls.

Design

Cohort

Follow-up

8+/-5 months

Authors

MSMatthew S. SuffolettoUniversity of PittsburghKDKaoru DohiCardiac ImagingMCMaxime CannessonCardiac Imaging

Discussion

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Implication

Speckle-tracking radial dyssynchrony may aid CRT candidate selection in HF; leaves open superiority to tissue Doppler pending randomized trials.

Structured PICO

Does speckle-tracking radial strain quantify dyssynchrony and predict response to cardiac resynchronization therapy in heart failure patients?

P
Population
74 subjects: 64 heart failure patients undergoing cardiac resynchronization therapy (CRT) (aged 64+/-12 years, ejection fraction 26+/-6%, QRS duration 157+/-28 ms) and 10 normal controls.
I
Intervention
Speckle-tracking radial strain from routine midventricular short-axis echocardiographic images to quantify mechanical dyssynchrony.
O
Outcome
Prediction of response to CRT, measured by immediate increase in stroke volume (1 day post-CRT) and significant increase in ejection fraction at long-term follow-up (8+/-5 months).surrogate

Speckle-tracking radial strain is a feasible echocardiographic method to quantify mechanical dyssynchrony and predict both immediate and long-term echocardiographic response to CRT in heart failure patients.

Cite This Study

Suffoletto et al. (2006) studied this question.

synapsesocial.com/papers/69f29d161b51e2fbf01873f3https://doi.org/10.1161/circulationaha.105.571455

Topics

HFrEF treatmentHeart failureEchocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Improved Left Ventricular Mechanics From Acute VDD Pacing in Patients With Dilated Cardiomyopathy and Ventricular Conduction Delay1999 · 977 citations
  2. 2Long-term benefits of biventricular pacing in congestive heart failure: results from the MUltisite STimulation in cardiomyopathy (MUSTIC) study2002 · 978 citations
  3. 3Effect of Resynchronization Therapy Stimulation Site on the Systolic Function of Heart Failure Patients2001 · 630 citations
  4. 4Strain rate imaging using two-dimensional speckle tracking2001 · 222 citations
  5. 5Tissue Doppler Imaging Is Superior to Strain Rate Imaging and Postsystolic Shortening on the Prediction of Reverse Remodeling in Both Ischemic and Nonischemic Heart Failure After Cardiac Resynchronization Therapy2004 · 626 citations